Autoinflammatory & rare systemic diseases
Arthroplasty rates and risk in familial Mediterranean fever patients: a large population-based study
Authors' conclusion
Although this complication is relatively uncommon in FMF patients, it occurs almost twice as frequently as compared with the general population. FMF patients of North African origin are at an even higher risk.
Study context
- Population
- FMF patients diagnosed 2000–2016 in the largest health-care organization in Israel and matched controls
- Exposure
- FMF vs matched controls
- FMFn = 9,769
- Outcome
- Rates of arthroplasty
Methodological detailspopulation-based, age-, gender- and residency-matched controls, logistic regression
- Population-based
- Age-, gender- and residency-matched controls
- Logistic regression
Main finding
As reported in the abstract
Arthroplasty
Each group vs controlsEstimate (95% CI)
FMF
OR (unadjusted) 1.79(1.32–2.43)
FMF
OR (partially adjusted) 1.97(1.40–2.77)
FMF
OR (fully adjusted) 1.92(1.35–2.72)
Observational data: associations, not effects.
Further findings
Arthroplasty risk within FMF cohort: North African origin
| OR (95% CI) | P value | ||
|---|---|---|---|
| North African origin | 6.89 (5.09–9.33) | P < 0.001 | |
| 0.10.31310Odds ratio (log scale) |
Original publication
Arthroplasty rates and risk in familial Mediterranean fever patients: a large population-based study. Rheumatology (Oxford). Published 5 February 2024. doi:10.
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