Autoinflammatory & rare systemic diseases
Susceptibility to mycobacterial infection in VEXAS syndrome
Authors' conclusion
VEXAS patients have an intrinsic susceptibility to disseminated NTMi, which may result from monocytic dysfunction. NTMi can mimic VEXAS flare.
Study context
- Population
- All patients with disseminated non-tuberculous mycobacterial infections seen at one institution over 13 years, including two VEXAS patients with disseminated Mycobacterium avium infectioncases of disseminated non-tuberculous mycobacterial infections (NTMi)
- Participants
- 20 patients
- Exposure
- HIV-negative vs HIV-positive patients with disseminated NTMi
- HIV-negativen = 11
- Outcome
- Underlying conditions in HIV-negative patients
Methodological detailssingle-centre, case report of two VEXAS patients
- Single-centre
- Case report of two VEXAS patients
Main finding
As reported in the abstract
- Chronic immune-mediated disease
- 3
- Untreated myeloid neoplasm
- 3
- VEXAS
- 2
- Kidney transplantation
- 1
- GATA-2 deficiency
- 1
- No identified aetiology
- 1
- Lymphoid neoplasia or bone marrow transplantation
- 0
Observational data: associations, not effects.
Further findings
CD4 count
P < 0.001
Monocytopenia
- Cases with monocytopenia
- 7
Death · 2 years
- Patients who had died, including both VEXAS patients
- 6
Original publication
Susceptibility to mycobacterial infection in VEXAS syndrome. Rheumatology (Oxford). Published 5 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →