Vasculitis & polymyalgia rheumatica
The clinical characteristics and treatment outcomes of patients with systemic polyarteritis nodosa: a single-centre study from India
Main finding · Relapse-free survival, MMF vs CYC inductionResult — go to the resultAHR for relapse 0.68Authors' conclusion
Mycophenolate was similar to cyclophosphamide in maintaining relapse-free survival.
Study context
- Population
- Patients with systemic PAN fulfilling American College of Rheumatology (ACR) 1990 criteria, single centre in India, last two decadestwo with hepatitis B infection
- Participants
- 53 patients
- Exposure
- Induction with mycophenolate vs cyclophosphamide
- Mycophenolaten = 26
- Cyclophosphamiden = 21reference
- Outcome
- Relapse-free survival
Methodological detailssingle-centre
- Single-centre
Main finding
Relapse-free survival, MMF vs CYC induction
AHR for relapse
0.68
As reported in the abstract
Observational data: associations, not effects.
Further findings
Relapse (patients with follow-up >3 months, n = 46)
- Patients relapsed
- 19 (41.3%)
- Median time to relapse, months (IQR 36.3-127.7)
- 82
Response (49 patients with follow-up; median follow-up 53.5 months)
- Complete response
- 43 (87.8%)
- Partial response
- 3 (6.1%)
Predictors of relapse
- Smoking history (independent predictor), HR
- 6.28, P = 0.013
- Age (protective), HR
- 0.94, P = 0.015
Mortality
- Fatality
- 5 (10%)
- Five-factor score (FFS) and BVAS at 3 months among predictors of mortality
FFS of 0 at presentation
- Patients
- 64.2%
Original publication
The clinical characteristics and treatment outcomes of patients with systemic polyarteritis nodosa: a single-centre study from India. Rheumatology (Oxford). Published 12 January 2025. doi:10.
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