Vasculitis & polymyalgia rheumatica
Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry
Authors' conclusion
The overall five-year age- and sex-adjusted cumulative mortality rate in GCA is similar compared to the general population.
Study context
- Population
- GCA patients in the ARTESER registry of the Spanish Society of Rheumatology, June 2013 to March 2019mean (SD) follow-up 2.18 (1.53) years
- Participants
- 1,200 patients
- Exposure
- GCA patients vs Spanish general population
- GCAn = 1,200
- Outcome
- Mortality rate (deaths per 1000 person-years), compared with the general population
- Follow-up
- 5 years
Methodological detailsmulticentre registry, Kaplan-Meier survival analysis, Cox regression
- Multicentre registry
- Kaplan-Meier survival analysis
- Cox regression
Main finding
As reported in the abstract
Age- and sex-adjusted cumulative mortality rate
GCA
19.75
Spanish general population
20.72
P = 0.559
Observational data: associations, not effects.
Further findings
| Outcome | Males | Females | P value |
|---|---|---|---|
| Cumulative mortality rate by sexMales vs Females | 59.04 | 29.06 | P < 0.001 |
Overall five-year cumulative mortality rate per 1000 patients/year · 5 years
- Overall five-year cumulative mortality rate (95%CI) per 1000 patients/year
- 37.86 (31.75-43.96)
Factors associated with mortality (multivariate Cox analysis)
- Older age, HR
- 1.11 (1.073-1.142) (95%CI)
- Male sex, HR
- 1.775 (1.214-2.594) (95%CI)
- Headache, HR
- 0.55 (0.362-0.843) (95%CI)
- High hemoglobin levels, HR
- 0.85 (0.744-0.970) (95%CI)
- Multivariate analysis
Original publication
Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry. Arthritis Res Ther. Published 7 January 2025. doi:10.
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