Vasculitis & polymyalgia rheumatica
Cerebrovascular accidents in giant cell arteritis: prevalence and predictive factors from the ARTESER registry
Authors' conclusion
The prevalence of CVA in patients with GCA is low, but increases the risk of mortality. The presence of TIA, LV involvement and visual manifestations are factors associated with increased risk of CVA.
Study context
- Population
- Patients with GCA diagnosed June 2013–March 2019, Spanish multicentre ARTESER registry (mean age 77.1 years, 70% females)
- Participants
- 1,540 patients
- Exposure
- GCA patients with cerebrovascular accidents (CVA) vs without CVA
- CVAn = 61
- Outcome
- Prevalence and predictive factors of CVA in GCA
- Follow-up
- At diagnosis
Methodological detailsmulticentre registry, multivariate logistic regression
- Multicentre registry
- Multivariate logistic regression
Main finding
As reported in the abstract
Prevalence of CVA
CVA
3.96%
61
- Factor associated with CVA: Transient ischaemic attack (TIA), OR
- 8.63 (95% CI 2.877-25.86)
- Factor associated with CVA: Large vessel (LV) involvement, OR
- 2.79 (95% CI 1.421-5.465)
- Factor associated with CVA: concomitant visual manifestations, OR
- 2.73 (95% CI 1.427-5.235)
Observational data: associations, not effects.
Further findings
Death during follow-up
P = 0.014
Prednisone dose at diagnosis
P < 0.001
| Outcome | CVA | Without CVA | P value |
|---|---|---|---|
| Cumulative prednisone dose during follow-up | 11 203.9 | 8,194.1 | P < 0.001 |
Original publication
Cerebrovascular accidents in giant cell arteritis: prevalence and predictive factors from the ARTESER registry. Rheumatology (Oxford). Published 7 February 2025. doi:10.
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