Vasculitis & polymyalgia rheumatica
Differences in phenotypes, treatments, and outcomes of ANCA-associated vasculitis across Europe, Japan and the USA in 2020
Authors' conclusion
Although the kidney failure-free survival was comparable across continents, regional differences existed in clinical phenotypes and therapeutic patterns.
Study context
- Population
- Patients with newly diagnosed or relapsing granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) in Europe, Japan and the USA, January to July 2020
- Participants
- 254 patients
- Exposure
- Europe vs Japan vs USA
- Europen = 137
- Japann = 73
- USAn = 44
- Outcome
- Composite of:
- Kidney failure
- Death
- Follow-up
- 52 weeks
Methodological detailsCox proportional hazard model, subgroup analyses
- Cox proportional hazard model
- Subgroup analyses
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Kidney failure · 52 weeks
Death · 52 weeks
CYC use
RTX use
Phenotype
- Japan: older, higher proportions of MPO-ANCA positivity and lung involvement vs Europe and USA
- eGFR at diagnosis varied across regions; highest dialysis requirement in USA
Original publication
Differences in phenotypes, treatments, and outcomes of ANCA-associated vasculitis across Europe, Japan and the USA in 2020. Rheumatology (Oxford). Published 9 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →