Ten-year radiographic and functional outcomes in rheumatoid arthritis patients in remission compared to patients in low disease activity
Authors' conclusion
RA patients in sustained SDAI remission have better long-term structural and functional outcomes in comparison to patients in sustained LDA.
Study context
- Population
- Patients with early rheumatoid arthritis (RA) from the ESPOIR cohort fulfilling the 2010 ACR/EULAR criteriaESPOIR cohort
- Participants
- 256 patients
- Exposure
- Sustained Simple Disease Activity Index (SDAI) remission vs sustained low disease activity (LDA) vs sustained moderate to high disease activity over 10 years
- Remissionn = 48
- LDAn = 139reference
- MDA or HDAn = 69
- Outcome
- mTSS progression over 10 years and HAQ-DI at 10 years
- Follow-up
- 10 years
Methodological detailslongitudinal latent process mixed model
- Longitudinal latent process mixed model
Main finding
As reported in the abstract
Structural progression (variation of mTSS) over 10 years
Remission
4.06
± 4.75
LDA
14.59
± 19.76
MDA or HDA
21.04
± 24.08
P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Remission | LDA | MDA or HDA | P value |
|---|---|---|---|---|
| HAQ-DI at 10 yearsRemission vs LDA · comparison across the 3 groups · co-primary outcome | 0.14 ± 0.33 | 0.53 ± 0.49 | 1.20 ± 0.62 | P < 0.001 |
Safety
Serious adverse events over 10 years
- Incidence, all patients
- 3.34/100 patient years
- No difference between the three groups
- About 3.34/100 patient years
Original publication
Ten-year radiographic and functional outcomes in rheumatoid arthritis patients in remission compared to patients in low disease activity. Arthritis Res Ther. Published 20 October 2023. doi:10.
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