Patient perspectives on tapering biologic or targeted synthetic therapy in well-controlled rheumatoid arthritis and comparison with providers’ perspectives
Authors' conclusion
Patients who have had well-controlled RA are more likely to consider tapering bDMARD/tsDMARD when not being treated with csDMARDs or glucocorticoids. Patients and providers shared similar concerns regarding long-term use and tapering of bDMARD/tsDMARD, but patients were more likely to consider a taper.
Study context
- Population
- Patients with well-controlled RA on bDMARD or tsDMARD, and their providerscompleted the survey
- Participants
- 62 vs 11
- Exposure
- Patients vs providers
- Patientsn = 62
- Providersn = 11reference
- Outcome
- Willingness to consider a bDMARD/tsDMARD taper and factors influencing it
Methodological detailsstandardized phone survey, univariate and multivariable regression
- Standardized phone survey
- Univariate and multivariable regression
Main finding
As reported in the abstract
Would consider a bDMARD/tsDMARD taper
Observational data: associations, not effects.
Further findings
Factors associated with considering a bDMARD/tsDMARD taper (patients)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Patients who thought their RA was well-controlledMore likely to consider a taper | 8.02 (2.15–29.99) | P = 0.002 | |
| Shorter RA durationMore likely to consider a taper if of shorter duration | 0.94 (0.89–0.99) | P = 0.02 | |
| Patients if olderLess likely to consider a taper | 0.95 (0.91–1.0) | P = 0.05 | |
| Patients treated with conventional synthetic DMARDsLess likely to consider a taper | 0.25 (0.07–0.86) | P = 0.0275 | |
| Patients treated with daily glucocorticoidsLess likely to consider a taper | 0.08 (0.02–0.44) | P = 0.0033 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Patient perspectives on tapering biologic or targeted synthetic therapy in well-controlled rheumatoid arthritis and comparison with providers’ perspectives. Rheumatology (Oxford). Published 19 October 2023. doi:10.
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