Comprehensive analysis of serum exosome-derived long non-coding RNAs (lncRNAs) and mRNAs from patients with rheumatoid arthritis
Authors' conclusion
These findings help to elucidate the role of serum exosomal lncRNAs and mRNAs in the specific mechanisms underlying RA.
Study context
- Population
- Patients with rheumatoid arthritis (RA), patients with osteoarthritis (OA) and healthy controls
- Comparison
- Serum exosomal lncRNA and mRNA profiles in RA vs OA and healthy controls
- Outcome
- Serum exosomal lncRNA and mRNA expression profiles in RA vs OA and healthy controls (sequencing, qRT-PCR, diagnostic AUC, immune cell infiltration)
Methodological detailshigh-throughput sequencing, qRT-PCR validation, ROC analysis, CIBERSORT digital cytometry
- High-throughput sequencing
- qRT-PCR validation
- ROC analysis
- CIBERSORT digital cytometry
Main finding
As reported in the abstract
AUC of combination of CCL5, MPIG6B and PFKP for differentiating RA from OA
0.845
Original publication
Comprehensive analysis of serum exosome-derived lncRNAs and mRNAs from patients with rheumatoid arthritis. Arthritis Res Ther. Published 16 October 2023. doi:10.
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