Defining Difficult‐to‐Treat Rheumatoid Arthritis in Routine Care: Comparative Performance of Published Criteria and Description of Early and Late Difficult‐to‐Treat Rheumatoid Arthritis Phenotypes
Authors' conclusion
The applications of D2T-RA criteria are not interchangeable and vary widely in patient capture. A two-year threshold anchored to the first initiation of advanced therapy offered a clinically balanced early-late D2T-RA framework.
Study context
- Population
- Patients with rheumatoid arthritis (RA) initiating their first advanced therapy, Ontario Best Practices Research Initiative registry (mean age 56.0 years; 80.7% female; mean disease duration 8.4 years)
- Participants
- 1,121 patients
- Exposure
- Four literature-derived adaptations of the EULAR difficult-to-treat RA (D2T-RA) definition
- Outcome
- Prevalence of D2T-RA by each definition and agreement between definitions
Methodological detailslongitudinal real-world RA registry, comparison of four literature-derived adaptations of the EULAR D2T-RA definition
- Longitudinal real-world RA registry
- Comparison of four literature-derived adaptations of the EULAR D2T-RA definition
Main finding
As reported in the abstract
Prevalence of D2T-RA
- Fulfilled at least one of four D2T-RA definitions
- 202 (18%)
- Patients meeting all definitions 1 through 3
- 44%
Observational data: associations, not effects.
Further findings
Early vs late D2T-RA, 2-year threshold anchored to initiation of first advanced therapy · two-year threshold
Approximately
- Early D2T-RA
- 40%
- Late D2T-RA
- 60%
Original publication
Defining Difficult‐to‐Treat Rheumatoid Arthritis in Routine Care: Comparative Performance of Published Criteria and Description of Early and Late Difficult‐to‐Treat Rheumatoid Arthritis Phenotypes. Arthritis Care Res (Hoboken). Published 15 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →