Increased expression of omentin-1 is associated with synovitis and bone destruction in rheumatoid arthritis
Authors' conclusion
Our results suggested that omentin-1 was up-regulated in RA and can exacerbate synovitis and joint destruction which may provide new insight into the pathogenesis of RA.
Study context
- Population
- Rheumatoid arthritis (RA) patients and normal population; Collagen-induced arthritis (CIA) mice
- Comparison
- RA patients vs healthy controls; omentin-1 injection in CIA mice
- Outcome
- Expression and role of omentin-1 in RA
Methodological detailscase-control serum comparison, collagen-induced arthritis mouse model
- Case-control serum comparison
- Collagen-induced arthritis mouse model
Main finding
As reported in the abstract
Correlation of omentin-1 with CRP
r=0.427
p=0.002
Correlation of omentin-1 with ESR
r=0.454
p<0.001
Correlation of omentin-1 with DAS28
r=0.496, p<0.001; r=0.661, p<0.001, respectively
Omentin-1 associated with disease activity state (multivariable analysis)
OR=1.018
p=0.004
Original publication
Increased expression of omentin-1 is associated with synovitis and bone destruction in rheumatoid arthritis. Clin Exp Rheumatol. Published 15 October 2023. doi:10.
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