Systemic inflammation response index as an emerging biomarker in osteoarthritis patients: a bibliometric and large sample retrospective investigation
Authors' conclusion
SIRI may serve as a non-invasive, appropriate biomarker to correlate with disease activity.
Study context
- Population
- Osteoarthritis (OA) patients and healthy controls
- Comparison
- OA vs healthy controls
- Outcome
- Value of whole-blood inflammatory response indices (NLR, PLR, MLR, SIRI) as biomarkers of disease activity in OA
Methodological detailsbibliometric approach, ROC curves, logistic regression
- Bibliometric approach
- ROC curves
- Logistic regression
Main finding
As reported in the abstract
Whole-blood inflammatory indices (NLR, PLR, MLR, SIRI)
- MLR, NLR, PLR and systemic inflammation response index (SIRI) markedly higher in OA than healthy controls (HC)
- On ROC curves, SIRI and NLR could separate OA from HC
- NLR, PLR, MLR and SIRI related to immune-inflammatory markers, visual analogue scale (VAS) scores and SF-36 scores
- On logistic regression, SIRI, NLR and C-reactive protein (CRP) forecasted disease activity; SIRI + CRP model superior to CRP alone
Observational data: associations, not effects.
Further findings
Bibliometric analysis of literature on OA and whole-blood inflammation indicators
- Pathophysiology of OA received most of the spotlight; top 3 key word clusters: "inflammation", "osteoarthritis" and "disease activity"
Original publication
Systemic inflammation response index as an emerging biomarker in osteoarthritis patients: a bibliometric and large sample retrospective investigation. Clin Exp Rheumatol. Published 3 May 2023. doi:10.
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