Synovial 5‐Lipoxygenase–Derived Oxylipins Define a Lympho‐Myeloid–Enriched Synovium
Authors' conclusion
The lack of correlation between ST and plasma oxylipins suggests that ST lipid profiling better characterizes active pathways in treated joints. Synovial 5-LOX-derived oxylipins were highly expressed in lympho-myeloid-enriched synovium.
Study context
- Population
- Patients with established RA or PsA with active disease despite treatment32 synovial tissue (ST) and 26 paired-plasma samples
- Outcome
- Correlation of synovial oxylipins with plasma oxylipins and with synovial histologic patterns
Methodological detailspaired synovial tissue and plasma, single-cell RNA sequencing data analysis
- Paired synovial tissue and plasma
- Single-cell RNA sequencing data analysis
Main finding
As reported in the abstract
Oxylipins identified in ST
71
Oxylipins identified in plasma
24
Observational data: associations, not effects.
Original publication
Synovial 5‐Lipoxygenase–Derived Oxylipins Define a Lympho‐Myeloid–Enriched Synovium. Arthritis Rheumatol. Published 1 May 2024. doi:10.
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