Association of the multi-biomarker disease activity score with arterial 18-fluorodeoxyglucose uptake in rheumatoid arthritis
Authors' conclusion
Among treated RA patients, achieved MBDA predicts changes in arterial inflammation.
Study context
- Population
- Rheumatoid arthritis (RA) patients with active disease despite MTXinterpretable scans at baseline and week 24
- Participants
- 112 patients
- Comparison
- Association of MBDA score with change in arterial inflammation (MDS-TBRmax) on FDG-PET/CT
- Primary endpoint
- Change in arterial inflammation (MDS-TBRmax of FDG uptake in carotid arteries or aorta) and its association with MBDA
- Follow-up
- 24 weeks
Primary result
As reported in the abstract
Correlation of week-24 MBDA score with change in MDS-TBRmax
Spearman's rho
0.239
P = 0.011
Further findings
Adjusted reduction in arterial inflammation by low MBDA at week 24
- Low MBDA: statistically significant adjusted reduction (units)
- 0.35
- Not achieving low MBDA: no significant reduction
DAS28-CRP and CRP
- Neither DAS28-CRP nor CRP predicted change in arterial inflammation
MBDA components
- Strongest association with change in arterial inflammation: serum amyloid A
Original publication
Association of the multi-biomarker disease activity score with arterial 18-fluorodeoxyglucose uptake in rheumatoid arthritis. Rheumatology (Oxford). Published 23 April 2024. doi:10.
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