Lipoxygenase-derived oxylipins are enriched in anti-citrullinated protein antibody (anti-citrullinated protein antibodies (ACPA))-positive individuals at risk for developing rheumatoid arthritis
Authors' conclusion
ACPA seropositivity in otherwise unaffected individuals at-risk for developing future RA based on family history (FDR) is associated with alterations in the serum oxylipin profile that suggests dysregulated LOX activity.
Study context
- Population
- First-degree relatives of rheumatoid arthritis (RA) patients at risk for developing RA4 ACPA+ first-degree relatives (FDR) developed RA
- Participants
- 31 vs 10
- Exposure
- ACPA-positive vs ACPA-negative first-degree relatives of RA patients
- ACPA+ FDRn = 31
- ACPA- FDRn = 10reference
- Outcome
- Serum fatty acids (gas chromatography (GC)) and oxylipins (HPLC/MS/MS)
Methodological detailsestablished cohort of first-degree relatives of RA patients
- Established cohort of first-degree relatives of RA patients
Main finding
As reported in the abstract
- No meaningful differences in overall fatty acid (FA) content between ACPA+ and ACPA- FDR
- Oxylipin levels differed significantly between groups; ACPA+ enriched in arachidonic acid- and eicosapentaenoic acid-derived molecules
- ACPA+ FDR, including those who progressed to inflammatory arthritis, had higher levels of LOX-derived oxylipins vs ACPA- FDR
Observational data: associations, not effects.
Original publication
Lipoxygenase-derived oxylipins are enriched in anti-citrullinated protein antibody (ACPA)-positive individuals at risk for developing rheumatoid arthritis. Arthritis Res Ther. Published 15 February 2024. doi:10.
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