Prednisone use, disease activity and the occurrence of hyperglycaemia and diabetes in patients with early rheumatoid arthritis: a 10-year subanalysis of the BeSt study
Authors' conclusion
In non-diabetic early RA patients, the use of prednisone was not associated with developing hyperglycaemia or diabetes. However, high DAS increased the risk of diabetes.
Study context
- Population
- Non-diabetic early rheumatoid arthritis (RA) patients from the BeSt study, randomised to four disease activity score (DAS)-steered treatment arms
- Participants
- 504 patients
- Comparison
- Prednisone use and DAS vs development of hyperglycaemia and diabetes
- Primary endpoint
- Development of hyperglycaemia and diabetes (glucose levels, occurrence of hyperglycaemia, diabetes)
- Follow-up
- 10 years
Methodological details10-year follow-up, linear and logistic mixed effects regression models, Cox regression, sensitivity analyses
- 10-year follow-up
- Linear and logistic mixed effects regression models
- Cox regression
- Sensitivity analyses
Primary result
As reported in the abstract
Diabetes during follow-up
31 of 504 patients
6.2%
Diabetes cases with prior prednisone treatment
11 of these
35%
DAS and development of diabetes, HR per 1 point DAS increase
1.802
95% CI 1.284 to 2.529
Further findings
Sensitivity analysis: patients with previous hyperglycaemia
- DAS associated with glucose levels, recurrence of hyperglycaemia and diabetes
Original publication
Prednisone use, disease activity and the occurrence of hyperglycaemia and diabetes in patients with early rheumatoid arthritis: a 10-year subanalysis of the BeSt study. RMD Open. Published 30 April 2024. doi:10.
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