Repair of joint damage in patients with rheumatoid arthritis does not relate to previous suppression of inflammation: a subanalysis after 8 years treat-to-target in the BeSt-trial
Authors' conclusion
After 8 years of treatment to target DAS≤2.4 in 508 patients with recent onset RA, repair of JSN and erosions was seen in 17/320 patients (5.3%).
Study context
- Population
- Patients with recent onset rheumatoid arthritis (RA) (1987 criteria) randomised to four treat-to-target strategies (Disease Activity Score (DAS)≤2.4)320 assessed for repair
- Participants
- 508 patients
- Primary endpoint
- Repair of joint damage (negative ΔSHS in an individual joint, seen by ≥3 of 4 readers, persisting ≥2 consecutive years) and its clinical predictors
- Follow-up
- 8 years
Methodological detailstreat-to-target (DAS≤2.4), 8-year follow-up, four treatment strategies, four independent readers, non-chronological scoring
- Treat-to-target (DAS≤2.4)
- 8-year follow-up
- Four treatment strategies
- Four independent readers, non-chronological scoring
Primary result
As reported in the abstract
Repair of joint damage (erosions or JSN)
Patients with repair
17 of 320
5.3%
Regression of joint space narrowing (JSN)
10
Regression of erosions
7
Both JSN and erosion regression
0
Original publication
Repair of joint damage in patients with rheumatoid arthritis does not relate to previous suppression of inflammation: a subanalysis after 8 years treat-to-target in the BeSt-trial. RMD Open. Published 25 April 2023. doi:10.
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