Endogenous Retroelement Activation is Implicated in Interferon‐α Production and Anti–Cyclic Citrullinated Peptide Autoantibody Generation in Early Rheumatoid Arthritis
Authors' conclusion
Peripheral blood and synovial ERE expression is examined for the first time in eRA, highlighting both a potential causal relationship between ERE and IFN-I production and an intriguing association with anti-CCP autoantibodies.
Study context
- Population
- Disease-modifying treatment-naïve early rheumatoid arthritis (RA) (whole blood and synovial tissue), with early PsA, established RA and osteoarthritis (OA) comparators
- Comparison
- ERE expression in early RA (eRA) vs ePsA and established RA vs OA
- Outcome
- ERE expression and its association with IFN-α and anti-CCP in eRA
Methodological detailsdisease-modifying treatment-naïve eRA, reanalysis of existing synovial single-cell sequencing data
- Disease-modifying treatment-naïve eRA
- Reanalysis of existing synovial single-cell sequencing data
Main finding
As reported in the abstract
- Coexpression of all ERE classes and IFNA in eRA synovial tissue (n = 22)
- P < 0.0001
- Whole-blood LINE-1 expression (n = 56) positively associated with circulating IFN-α protein
- P = 0.018
- Whole-blood LINE-1 expression positively associated with anti-cyclic citrullinated peptide (anti-CCP) titers
- P < 0.0001
Original publication
Endogenous Retroelement Activation is Implicated in Interferon‐α Production and Anti–Cyclic Citrullinated Peptide Autoantibody Generation in Early Rheumatoid Arthritis. Arthritis Rheumatol. Published 27 January 2025. doi:10.
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