Subclinical macular vessel density alterations in patients with juvenile systemic lupus erythematosus
Authors' conclusion
We demonstrated decreased VD in all layers of the retina and CC in patients with JSLE without ocular involvement.
Study context
- Population
- Children with juvenile SLE without ocular involvement and healthy controlsone eye per participant
- Participants
- 29 vs 29
- Exposure
- Juvenile SLE vs healthy controls
- Juvenile systemic lupus erythematosus (JSLE)n = 29
- Healthy controlsn = 29reference
- Outcome
- Macular VD of SCP, ICP, DCP, CC and FAZ area on OCT angiography
Methodological detailsmultiple linear regression
- Multiple linear regression
Main finding
As reported in the abstract
Macular microvasculature (OCTA), JSLE vs healthy controls
- Superficial capillary plexus (SCP) vessel density (VD) total significantly lower in JSLE
- p = .007
- SCP VD superior quadrant significantly lower in JSLE
- p = .014
- SCP VD inferior quadrant significantly lower in JSLE
- p = .004
- Intermediate capillary plexus (ICP) VD total and all quadrants decreased in JSLE
- p = .015, p = .0045, p = .015, p = .033
- ICP VD temporal quadrant: no decrease
- p = .366
- Deep capillary plexus (DCP) VD total significantly decreased in JSLE
- p = .011
- DCP VD superior quadrant significantly decreased in JSLE
- p<.01
- CC VD total decreased in JSLE
- p = .003
- CC VD nasal quadrant decreased in JSLE
- p = .017
- No significant difference in foveal avascular zone (FAZ) area between groups
- p = .774
Observational data: associations, not effects.
Further findings
Effect of disease duration and activity on optical coherence tomography angiography (OCTA) parameters (multiple linear regression adjusted for age, spherical equivalent, intraocular pressure)
- No contributing factor to OCTA parameters was found
Original publication
Subclinical macular vessel density alterations in patients with juvenile systemic lupus erythematosus. Lupus. Published 1 November 2023. doi:10.
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