Systemic sclerosis & Raynaud's
Steady decrease in systemic sclerosis mortality rates at younger ages over the past five decades
Authors' conclusion
Mortality for SSc has steadily decreased at younger ages over the past five decades.
Study context
- Population
- All US residents, 1968 through 2015; decedents with SSc recorded as the underlying cause of deathSSc decedents by age group
- Participants
- 5,457 / 18,395 / 22,946
- Exposure
- SSc vs all other causes of death, by age group, 1968–2015
- ≤44 yearsn = 5,457
- 45-64n = 18,395
- ≥65n = 22,946
- Outcome
- SSc mortality by age: proportion of deaths, ASMR and SSc-ASMR:non-SSc-ASMR ratio, as AAPC
- Follow-up
- 1968 through 2015
Methodological detailsnational mortality database, US census data, joinpoint regression
- National mortality database
- US census data
- Joinpoint regression
Main finding
As reported in the abstract
SSc mortality trends by age
- Ages ≤44: Average annual percent change (AAPC) in proportion of annual deaths, SSc
- −2.2% (95% CI, −2.4% to −2.0%)
- Ages ≤44: AAPC in proportion of annual deaths, non-SSc (−1.9% to −1.1%)
- −1.5%
- Ages ≤44: SSc-ASMR per million persons, 1968
- 1.0 (95% CI, 0.8-1.2)
- Ages ≤44: SSc-ASMR per million persons, 2015 (0.3-0.5)
- 0.4
- Ages ≤44: SSc-ASMR cumulative decrease
- 60%
- Ages ≤44: SSc-ASMR AAPC
- −1.9% (95% CI, −2.5% to −1.2%)
- Ages ≤44: SSc-ASMR:non-SSc-ASMR ratio cumulative change
- −20%
- Ages ≤44: SSc-ASMR:non-SSc-ASMR ratio AAPC
- −0.3% (95% CI, −1.15% to 0.55%)
- Ages ≥65: SSc-ASMR cumulative increase
- 187.0%
- Ages ≥65: SSc-ASMR AAPC
- 2.0% (95% CI, 1.8-2.2)
- Ages ≥65: SSc-ASMR:non-SSc-ASMR ratio cumulative increase
- 395.4%
- Ages ≥65: SSc-ASMR:non-SSc-ASMR ratio AAPC
- 3.3% (95% CI, 2.9-3.7)
Observational data: associations, not effects.
Original publication
Steady decrease in systemic sclerosis mortality rates at younger ages over the past five decades. Rheumatology (Oxford). Published 22 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →