Systemic sclerosis & Raynaud's
Characteristics of ScleroID highlighting musculoskeletal and internal organ implications in patients afflicted with systemic sclerosis
Authors' conclusion
In a large single-centre cohort, the previously described ScleroID-related findings were confirmed. Furthermore, several organ involvement-related functional and performance tests showed a good correlation to the ScleroID including the 6MWT and gastrointestinal-related complaints.
Study context
- Population
- Consecutive patients with systemic sclerosis (SSc) at a large tertiary care centre (median age 46 (43;56) years; diffuse cutaneous SSc 55%)
- Participants
- 160 patients
- Outcome
- Correlation between the ScleroID and organ system involvement and disease activity/damage
Methodological detailssingle-centre, consecutive patients, tertiary care centre
- Single-centre
- Consecutive patients
- Tertiary care centre
Main finding
As reported in the abstract
Correlation of ScleroID with organ involvement, function and disease activity
Negative correlation with 6MWT (rho)
rho - 0.444
p < 0.001
Positive correlation with Mouth Handicap in the Scleroderma Scale (rho)
rho: 0.626
p < 0.001
Positive correlation with UCLA SCTC GIT 2.0 (rho)
rho: 0.646
p < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Oesophageal difficulties | Normal oesophagus | P value |
|---|---|---|---|
| ScleroID score, oesophageal difficulties vs normal oesophagus | 3.2 (IQR 1.5–4.5) | 2.2 (IQR 1.0–3.2) | P = 0.011 |
Original publication
Characteristics of ScleroID highlighting musculoskeletal and internal organ implications in patients afflicted with systemic sclerosis. Arthritis Res Ther. Published 20 May 2023. doi:10.
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