Systemic sclerosis & Raynaud's
Factors associated with shorter time to death and causes of mortality among deceased patients with systemic sclerosis: a multicentre retrospective study
Authors' conclusion
Pulmonary complications predominated among SSc-related deaths, whereas cardiovascular disease, infections, and malignancy were the leading contributors to non-SSc-related mortality.
Study context
- Population
- Deceased patients aged ≥16 years with systemic sclerosis (SSc) (2013 ACR/EULAR criteria), 19 tertiary rheumatology centres in Turkey, 2004–2024of 294 identified
- Participants
- 266 patients
- Exposure
- SSc-related deaths vs Non-SSc-related deaths
- SSc-related deathsn = 122
- Non-SSc-related deathsn = 144
- Outcome
- Causes of death and clinical factors associated with shorter time to death (interval from diagnosis to death)
Methodological detailsmulticentre, 19 tertiary rheumatology centres, cause-specific Cox regression, Dates of death verified through the national death registry
- Multicentre
- 19 tertiary rheumatology centres
- Cause-specific Cox regression
- Dates of death verified through the national death registry
Main finding
As reported in the abstract
Causes of death
| Group | Value | Interstitial lung disease (ILD) | Pulmonary arterial hypertension (PAH) | Cardiovascular causes | Infections | Malignancy |
|---|---|---|---|---|---|---|
| SSc-related deaths | 45.9% | 50.0%, n = 61 | 42.6%, n = 52 | |||
| Non-SSc-related deaths | 54.1% | 38.9%, n = 56 | 33.3%, n = 48 | 19.4%, n = 28 |
Value
SSc-related deaths45.9%
Non-SSc-related deaths54.1%
Interstitial lung disease (ILD)
SSc-related deaths50.0%, n = 61
Non-SSc-related deaths— not stated in the abstract
Pulmonary arterial hypertension (PAH)
SSc-related deaths42.6%, n = 52
Non-SSc-related deaths— not stated in the abstract
Cardiovascular causes
SSc-related deaths— not stated in the abstract
Non-SSc-related deaths38.9%, n = 56
Infections
SSc-related deaths— not stated in the abstract
Non-SSc-related deaths33.3%, n = 48
Malignancy
SSc-related deaths— not stated in the abstract
Non-SSc-related deaths19.4%, n = 28
Observational data: associations, not effects.
Original publication
Factors associated with shorter time to death and causes of mortality among deceased patients with systemic sclerosis: a multicentre retrospective study. Scand J Rheumatol. Published 20 August 2026. doi:10.
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