Systemic sclerosis & Raynaud's
Sleep Disorders in Patients with Systemic Sclerosis: A Systematic Review and Meta-Analysis
Authors' conclusion
Available evidence suggests that sleep disorders may affect approximately three quarters of patients with systemic sclerosis when assessed by the PSQI, and obstructive sleep apnea may affect more than one third when evaluated by objective tools. These estimates carry low GRADE certainty and wide prediction intervals, and should not be interpreted as definitive prevalence figures. Larger prospective studies and well-powered randomised trials are needed to establish more precise estimates and to evaluate targeted sleep interventions in this population.
Study context
- Population
- Adults with systemic sclerosispatients in twenty-three studies included across all analyses · Primary meta-analysis of poor sleep quality (PSQI), eleven studies 820 · Obstructive sleep apnea meta-analysis, five studies 346
- Participants
- 1,487 adults
- Outcome
- Pooled prevalence of poor sleep quality assessed by the Pittsburgh Sleep Quality Index
Methodological detailsrandom-effects model, logit transformation, Hartung-Knapp correction, registered in PROSPERO
- Random-effects model
- Logit transformation
- Hartung-Knapp correction
- Registered in PROSPERO
Pooled result
As reported in the abstract
Pooled prevalence of poor sleep quality (95% CI 66.62 to 84.13%)
76.49%
I²
70.1%
95% prediction interval
49.66% to 91.47%
Further pooled results
Pooled prevalence of obstructive sleep apnea
- Pooled prevalence (95% CI 25.56 to 57.04%)
- 40.30%
- I²
- 71.8%
- 95% prediction interval
- 13.95% to 73.75%
Publication bias (Egger's test and trim-and-fill)
- Studies imputed by trim-and-fill
- four
- Corrected estimate of poor sleep quality prevalence (95% CI 57.33 to 79.63%)
- 69.62%
- Egger's test identified possible funnel plot asymmetry
- Somewhat lower than the primary estimate
Certainty of evidence (GRADE)
- Rated as low
Original publication
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