Sjögren's disease & overlap diseases
Sjögren's disease and systemic lupus erythematosus overlap syndrome as distinct entity at crossroads of two autoimmune disorders: clinical characterisation from two Italian reference centres for both the diseases
Authors' conclusion
Our data further highlight the limitations of the application of the current classification criteria in overlap syndrome, since they are primarily based on clinical manifestations and common autoantibodies.
Study context
- Population
- Patients with SjD-SLE overlap syndrome, Sjögren's disease (SjD) or systemic lupus erythematosus (SLE), two Italian rheumatology centres
- Exposure
- SjD-SLE overlap syndrome vs SjD only and vs SLE only
- Outcome
- Clinical, serological, US and histological features, SjD-SLE vs SjD controls
Methodological detailstwo Italian rheumatology reference centres, consecutive patients, comparison with SjD-only and SLE-only controls
- Two Italian rheumatology reference centres
- Consecutive patients
- Comparison with SjD-only and SLE-only controls
Main finding
As reported in the abstract
- Schirmer's test and parotid swelling comparable between the two groups
- US changes in the major salivary glands prevalent in SjD controls
- Histological findings of the minor salivary glands similar
- SjD-SLE vs SjD controls: P < 0.0001
- SjD-SLE vs SjD controls: P = 0.0001
- SjD-SLE vs SjD controls: P = 0.009
- SjD-SLE vs SjD controls: P < 0.0001
- SjD-SLE vs SjD controls: P = 0.001
- SjD-SLE vs SjD controls: P < 0.0001
- SjD-SLE vs SjD controls: P < 0.0001
- SjD-SLE vs SjD controls: P = 0.008
- SjD-SLE vs SjD controls: P = 0.035
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Clinical and serological features, SjD-SLE vs SLE controlsSjD-SLE vs SLE controls · older | P = 0.044 |
| Clinical and serological features, SjD-SLE vs SLE controlsSjD-SLE vs SLE controls · higher prevalence of anti-SSA and anti-SSB | P < 0.0001 |
| Clinical and serological features, SjD-SLE vs SLE controlsSjD-SLE vs SLE controls · C4 reduction | P = 0.011 |
| Clinical and serological features, SjD-SLE vs SLE controlsSjD-SLE vs SLE controls · leukopenia | P = 0.025 |
Clinical and serological features, SjD-SLE vs SLE controls
- Frequency of extra-glandular manifestations similar to SLE, including renal involvement
Original publication
Sjögren's disease and systemic lupus erythematosus overlap syndrome as distinct entity at crossroads of two autoimmune disorders: clinical characterisation from two Italian reference centres for both the diseases. Clin Exp Rheumatol. Published 24 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →