Sjögren's disease & overlap diseases
Significant association of CX3CR1+CD8 T cells with aging and distinct clinical features in Sjögren's syndrome and IgG4-related disease
Authors' conclusion
CX3CR1+CD8 T cells might be involved in immune aging and distinct clinical phenotypes of patients with pSS or IgG4-RD.
Study context
- Population
- Consecutive patients with active, treatment-naïve primary Sjögren's syndrome (pSS) or IgG4-related disease (IgG4-RD), and healthy individuals
- Participants
- 57 / 54 / 40
- Exposure
- pSS vs IgG4-RD vs healthy individuals
- pSSn = 57
- IgG4-RDn = 54
- Healthy individualsn = 40reference
- Outcome
- Associations of peripheral CX3CR1+CD4 and CX3CR1+CD8 T cells with aging and clinical features
Methodological detailsconsecutive patients, flow cytometry
- Consecutive patients
- Flow cytometry
Main finding
As reported in the abstract
- CX3CR1+CD4 and CX3CR1+CD8 T cells selectively expressed perforin and granzyme B
- CX3CR1+CD4 and CX3CR1+CD8 T-cell proportions significantly higher in pSS and IgG4-RD than in healthy individuals
- Higher CX3CR1+CD8 proportions associated with aging in pSS and IgG4-RD but not in healthy individuals
- Sex not associated with CX3CR1+CD8 proportions
- pSS with ILD: higher CX3CR1+CD8 proportions than pSS without ILD
- IgG4-RD with retroperitoneal fibrosis and/or aortitis: higher CX3CR1+CD8 proportions than with Mikulicz's disease
- CX3CR1+CD8 proportions decreased after GC treatment in parallel with clinical improvement in IgG4-RD
Observational data: associations, not effects.
Original publication
Significant association of CX3CR1+CD8 T cells with aging and distinct clinical features in Sjögren's syndrome and IgG4-related disease. Clin Exp Rheumatol. Published 4 March 2023. doi:10.
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