Spondyloarthritis & psoriatic arthritis
Sex-specific diagnostic efficacy of MRI in axial spondyloarthritis: challenging the ‘One Size Fits All’ notion
Authors' conclusion
The diagnostic performance of structural MRI markers is substantially lower in female patients with axSpA; active inflammatory lesions show comparable performance in both sexes, while still overall inferior to structural markers.
Study context
- Population
- Patients with back pain from six prospective cohorts; Axial spondyloarthritis (axSpA) vs chronic low back pain controls; clinical diagnosis as reference standard1,194 screened
- Participants
- 526 patients
- Comparison
- Diagnostic performance of MRI findings in men vs women with axSpA
- Menn = 243
- Womenn = 136
- Controlsn = 147reference
- Outcome
- Diagnostic performance (DOR from LR+/LR-) of MRI findings (ankylosis, erosion, sclerosis, fat metaplasia, bone marrow oedema) by sex
Methodological detailspost hoc analysis, six prospective cohorts, two blinded independent readers
- Post hoc analysis
- Six prospective cohorts
- Two blinded independent readers
Performance
As reported in the abstract
Diagnostic performance of MRI lesions by sex
- Bone marrow oedema diagnostic OR (DOR), men
- 3.0
- Bone marrow oedema DOR, women
- 3.9
- Fat metaplasia DOR, men
- 37.9
- Fat metaplasia DOR, women
- 5.0
- Erosions specificity, women vs men
- 77% vs 87%
- Sclerosis specificity, women vs men
- 44% vs 66%
- Fat metaplasia specificity, women vs men
- 87% vs 96%
Original publication
Sex-specific diagnostic efficacy of MRI in axial spondyloarthritis: challenging the ‘One Size Fits All’ notion. RMD Open. Published 29 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →