Spondyloarthritis & psoriatic arthritis
Sex differential impact of comorbidities in spondyloarthritis: data from COMOSPA study
Authors' conclusion
Comorbidities exert distinct influences on disease activity, physical function and health-related quality of life in male and female patients with SpA.
Study context
- Population
- Patients with spondyloarthritis (SpA) in the COMOSPA study (65% male, mean age 43.6 years)65% male
- Participants
- 3,982 patients
- Comparison
- Female vs male patients with SpA
- Primary endpoint
- Prevalence of comorbidities by sex and their impact on disease outcomes (BASDAI, ASDAS, BASFI, European health-related quality of life questionnaire)
Methodological detailslogistic regression, linear models with sex × comorbidity interaction, adjusted for age and b/tsDMARD treatment
- Logistic regression
- Linear models with sex × comorbidity interaction
- Adjusted for age and b/tsDMARD treatment
Primary result
As reported in the abstract
- Similar comorbidity profiles in males and females, except lower prevalence of FM in males
- Higher prevalence in males of certain cardiovascular risk factors (hypertension, dyslipidaemia, renal impairment, ischaemic heart disease)
- Comorbidities, especially FM, correlated with higher disease activity, decreased physical function and reduced health-related quality of life in both sexes
- Peptic ulcers and high waist circumference had a greater impact on disease activity in females (higher impact in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) than in Ankylosing Spondylitis Disease Activity Score (ASDAS))
- Osteoporosis had a more pronounced effect on physical function in males
Original publication
Sex differential impact of comorbidities in spondyloarthritis: data from COMOSPA study. RMD Open. Published 30 January 2024. doi:10.
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