Sex differences in idiopathic inflammatory myopathies: insights from a large multicentre observational study
Authors' conclusion
These findings highlight relevant sex-related differences in clinical expression and may support more personalised management strategies.
Study context
- Population
- Idiopathic inflammatory myopathies (IIMs) patients from 5 tertiary Rheumatology Units across Italy
- Participants
- 228 patients5 tertiary centres
- Exposure
- Male vs female patients with IIMs
- Malen = 71
- Femalen = 157reference
- Outcome
- Sex differences in clinical phenotype, serological features and disease activity (MYOACT)
Methodological detailsmulticentre, cross-sectional comparison by sex, multivariable linear regression
- Multicentre
- Cross-sectional comparison by sex
- Multivariable linear regression
Main finding
As reported in the abstract
Disease activity (MYOACT)
- Males showed significantly higher disease activity by MYOACT
- Age at diagnosis similar between sexes
Observational data: associations, not effects.
Further findings
Independent factors of disease activity (multivariable linear regression)
- Male sex, MDA5 autoantibody positivity and greater damage extent associated with higher disease activity
- DM and PM associated with lower disease activity
MYOACT prediction of ICU admission
- Good predictive ability; optimal threshold
- 0.23
Original publication
Sex differences in idiopathic inflammatory myopathies: insights from a large multicentre observational study. Clin Exp Rheumatol. Published 20 September 2025. doi:10.
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