Spondyloarthritis & psoriatic arthritis
Sex differences in cardiovascular and disease-related features in axial spondyloarthritis. A multicenter study of 912 patients
Authors' conclusion
Disease-related features may influence the expression of atherosclerosis in patients with axSpA.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) in the Spanish AtheSpAin cohort
- Participants
- 301 vs 611
- Exposure
- Women vs men with axSpA
- Womenn = 301
- Menn = 611reference
- Outcome
- CV disease (carotid US findings and CV events) by sex
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
CV disease by sex
- Classic cardiovascular (CV) risk factors significantly less prevalent in women
- After adjustment for classic CV risk factors, only the carotid intima-media thickness (IMT) difference remained statistically significant
- Women vs Men: P = 0.001
- Women vs Men: P < 0.001
- Women vs Men: P = 0.008
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Disease-related features by sexWomen vs Men · higher ESR at diagnosis in women | P = 0.038 |
| Disease-related features by sexWomen vs Men · higher ASDAS in women | P = 0.012 |
| Disease-related features by sexWomen vs Men · higher BASDAI in women | P < 0.001 |
| Disease-related features by sexWomen vs Men · shorter disease duration in women | P < 0.001 |
| Disease-related features by sexWomen vs Men · lower prevalence of psoriasis in women | P = 0.008 |
| Disease-related features by sexWomen vs Men · lower mSASSS in women | P < 0.001 |
| Disease-related features by sexWomen vs Men · less mobility limitation (BASMI) in women | P = 0.033 |
| Carotid plaques, low-moderate CV risk SCORE category (subgroup) | P = 0.050 |
| Carotid plaques, high-very high CV risk SCORE category (subgroup) | P = 0.028 |
- Carotid plaques, low-moderate CV risk Systematic Coronary Risk Evaluation (SCORE) category (subgroup): more carotid plaques in men; also longer disease duration (p = 0.004), higher mSASSS (p = 0.001), psoriasis (p = 0.023)
- Carotid plaques, high-very high CV risk SCORE category (subgroup): more carotid plaques in women; also worse BASFI (p = 0.011), BASDAI (p<0.001), ASDAS (p = 0.027)
Original publication
Sex differences in cardiovascular and disease-related features in axial spondyloarthritis. A multicenter study of 912 patients. Semin Arthritis Rheum. Published 29 March 2023. doi:10.
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