Spondyloarthritis & psoriatic arthritis
Sex-specific impact of inflammation on traditional cardiovascular risk factors and atherosclerosis in axial spondyloarthritis. A multicentre study of 913 patients
Authors' conclusion
Inflammation is associated with atherosclerosis and CV disease in axSpA. A gender-driven effect is observed in this relationship.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) from the Spanish multicentre AtheSpAin cohort611 men and 302 women
- Participants
- 611 vs 302
- Exposure
- Men vs Women
- Menn = 611
- Womenn = 302
- Outcome
- Association of inflammation with CV risk factors and atherosclerosis, by sex
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
C reactive protein (CRP) inversely associated with HDL-cholesterol in men
β coefficient −1.2 mg/dL
95% CI −0.3 to −0.07p=0.001
ESR positively associated with triglycerides in women
β coefficient 0.6 mg/dL
95% CI 0.04 to 1p=0.035
Observational data: associations, not effects.
Original publication
Sex-specific impact of inflammation on traditional cardiovascular risk factors and atherosclerosis in axial spondyloarthritis. A multicentre study of 913 patients. RMD Open. Published 28 June 2024. doi:10.
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