Spondyloarthritis & psoriatic arthritis
Disease activity and hyperuricemia predict the development of cardiovascular events in patients with Psoriatic Arthritis: results of the 10-year prospective evaluation in the CARdiovascular in RheuMAtology (CARMA) cohort
Authors' conclusion
Disease activity and elevated urate levels independently predict CV events in PsA, highlighting their value as markers of CV risk beyond traditional factors captured by the PREVENT-CVD score.
Study context
- Population
- Psoriatic arthritis (PsA) patients without prior cardiovascular (CV) events from the CARMA project, 67 Spanish hospitals, enrolled July 2010–January 2012682 analysed
- Participants
- 725 patients
- Exposure
- Predictors of CV events in PsA
- CV eventsn = 85
- Outcome
- CV events
- Follow-up
- 10 years
Methodological detailsmulticentre, 10-year prospective follow-up, Cox regression, crude and adjusted for PREVENT-CVD score
- Multicentre
- 10-year prospective follow-up
- Cox regression, crude and adjusted for PREVENT-CVD score
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Highest tertile of DAS28-ESRadjusted for PREVENT-CVD
1.79(1.03–3.14)
P = 0.04Urate highest tertilecrude model
1.88(1.11–3.20)
P = 0.02Urate ≥9.0 mg/dlvs <6.5 mg/dladjusted model; strata <6.5, 6.5-8.9, ≥9.0 mg/dl
3.50(1.10–11.2)
P = 0.02- HAQ third tertile · crude analysis; did not persist after adjustment
- HR 1.70; P = 0.04
- 85 patients (12.46%) experienced CV events over 6397 patient-years
- 1.33 per 100 patient-years
Observational data: associations, not effects.
Further findings
Baseline characteristics, CV events vs no CV events
P < 0.001
Male CV events 68.2% · No CV events 51.9%
Hypertension CV events 60.0% · No CV events 21.8%
Diabetes CV events 18.8% · No CV events 6.0%
Dyslipidemia CV events 56.5% · No CV events 29.8%
| Outcome | P value |
|---|---|
| Baseline characteristics, CV events vs no CV events | P = 0.005 |
| Baseline characteristics, CV events vs no CV events | P < 0.001 |
| Baseline characteristics, CV events vs no CV events | P = 0.001 |
| Baseline characteristics, CV events vs no CV events | P < 0.001 |
- Baseline characteristics, CV events vs no CV events — Greater abdominal perimeter and BMI in patients with CV events
- p < 0.05 for both
Original publication
Disease activity and hyperuricemia predict the development of cardiovascular events in patients with Psoriatic Arthritis: results of the 10-year prospective evaluation in the CARMA cohort. Semin Arthritis Rheum. Published 11 January 2026. doi:10.
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