Serum levels of soluble urokinase plasminogen activator receptor in juvenile idiopathic arthritis: a single-center Swedish case-control study
Authors' conclusion
Our results indicate that, apart from RF and anti-CCP, analysis of suPAR could be of additional value in assessing the risk of erosions.
Study context
- Population
- Patients with JIA and age- and sex-matched controls, single centre, Sweden; patients followed clinically over 3 years
- Participants
- 51 vs 50
- Comparison
- JIA vs age- and sex-matched controls
- JIAn = 51
- Controlsn = 50reference
- Outcome
- Serum suPAR levels
Methodological detailssingle-centre, age- and sex-matched controls, Joint erosions evaluated by radiography; ESR, CRP, rheumatoid factor (RF) and anti-CCP analysed as part of clinical routine
- Single-centre
- Age- and sex-matched controls
- Joint erosions evaluated by radiography; ESR, CRP, RF and anti-CCP analysed as part of clinical routine
Main finding
As reported in the abstract
- Soluble urokinase plasminogen activator receptor (suPAR) levels did not differ significantly between JIA patients and controls
Observational data: associations, not effects.
Further findings
suPAR in polyarticular involvement (subgroup)
- Higher suPAR in patients with polyarticular involvement
- P = 0.013
suPAR and joint erosions
- Elevated suPAR associated with joint erosions
- P = 0.026
- RF/anti-CCP negative individuals with erosions who showed high suPAR
- 2
Original publication
Serum levels of soluble urokinase plasminogen activator receptor in juvenile idiopathic arthritis: a single-center Swedish case-control study. Pediatr Rheumatol Online J. Published 29 May 2023. doi:10.
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