Associations of infection burden with Kawasaki disease in a population-based setting during 30 years
Authors' conclusion
The findings suggest that infections are closely linked with Kawasaki disease, and with a wider temporal association than previously known.
Study context
- Population
- All cases of Kawasaki disease diagnosed in Sweden 1987–2018 and matched general-population controls; infection data from the Swedish National Patient Registercases 61% male
- Participants
- 1,774 vs 17,731
- Comparison
- Kawasaki disease cases vs matched population controls: history of infections
- Casesn = 1,774
- Controlsn = 17,731reference
- Outcome
- History of infections (association with Kawasaki disease)
Methodological detailsnationwide, population-based, matched on sex, age and area of residency
- Nationwide
- Population-based
- Matched on sex, age and area of residency
Main finding
As reported in the abstract
History of infections and KD
History of infections associated with KD, OR
2.3
95% CI 2.0 to 2.5
Observational data: associations, not effects.
Further findings
Infections by organ system
- Respiratory, skin, urogenital and gastrointestinal tract infections were all associated with KD
Infections 15-28 days before KD diagnosis · 15-28 days prior KD
- Infections associated with KD, OR
- 5.1 (95% CI 3.6 to 7.1)
Infections 181-365 days before KD diagnosis · 181-365 days prior KD
- Infections associated with KD, OR
- 1.3 (95% CI 1.1 to 1.6)
Repeated infections (dose-response)
- Dose-response relationship: repeated infections associated with higher ORs of KD
Original publication
Associations of infection burden with Kawasaki disease in a population-based setting during 30 years. RMD Open. Published 20 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →