Screening for comorbid autoimmune disease should be considered in children with antinuclear antibody (ANA) positive juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort
Main finding · Autoimmune diseases in generalResult — go to the resultHazard ratio 4.11 95% CI 2.13–7.91Authors' conclusion
Individuals with JIA have a significantly increased risk of being diagnosed with an autoimmune condition after receiving their JIA diagnosis compared to matched references. ANA positivity is associated with a further increased risk.
Study context
- Population
- Population-based juvenile idiopathic arthritis (JIA) cohort, southern Sweden, diagnosed 2000–2010, followed until 2019matched cohort
- Participants
- 302 vs 1,510
- Exposure
- JIA cohort vs age- and sex matched reference population
- JIAn = 302
- Reference populationn = 1,510reference
- Outcome
- Comorbid autoimmune conditions diagnosed after JIA diagnosis
Methodological detailsage- and sex matched reference population, Cox proportional models, validated JIA diagnosis
- Age- and sex matched reference population
- Cox proportional models
- Validated JIA diagnosis
Main finding
Autoimmune diseases in general · within the first 7 years of disease
Hazard ratio
4.11
95% CI 2.13–7.91
By group
JIA
7.7%
JIAvs Reference population
HR 4.11 (95% CI 2.13–7.91)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Coeliac disease | 5.24 (1.76–15.65) | |
| Hypothyroidism | 3.74 (1.14–12.30) | |
| 0.050.21520Hazard ratio (log scale) |
Comorbid autoimmune disease by ANA positivity, within JIA cohort
| HR (95% CI) | ||
|---|---|---|
| ANA positiveSignificantly increased risk | 6.21 (1.64–23.55) | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Screening for comorbid autoimmune disease should be considered in children with ANA positive juvenile idiopathic arthritis – results from the south-Swedish juvenile idiopathic arthritis cohort. Pediatr Rheumatol Online J. Published 19 October 2024. doi:10.
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