Role of high-temperature requirement serine protease A 2 in rheumatoid inflammation
Authors' conclusion
HtrA2 is a novel inflammatory mediator and a potential target for the development of an anti-inflammation therapy for RA.
Study context
- Population
- Synovial tissue and synovial fluid of patients with rheumatoid arthritis (RA) and osteoarthritis (OA); primary RA synoviocytes
- Comparison
- RA vs OA synovial fluid and tissue; HtrA2 knockdown in RA synoviocytes
Main finding
As reported in the abstract
- HtrA2 concentration higher in RA synovial fluid (SF) than in OA SF
- HtrA2 in RA SF correlated with number of immune cells
- HtrA2 in RA SF elevated in proportion to synovitis severity; correlated with IL-6, IL-8 and CCL2
- HtrA2 highly expressed in RA synovium and primary synoviocytes
- RA synoviocytes released HtrA2 when stimulated with ER stress inducers
- HtrA2 knockdown inhibited IL1β-, TNFα- and LPS-induced release of proinflammatory cytokines and chemokines by RA synoviocytes
Original publication
Role of high-temperature requirement serine protease A 2 in rheumatoid inflammation. Arthritis Res Ther. Published 7 June 2023. doi:10.
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