The course of cytokine and chemokine gene expression in clinically suspect arthralgia patients during progression to inflammatory arthritis
Authors' conclusion
Whole-blood gene expression of assessed cytokines, chemokines and related receptors did not change significantly from CSA to IA development.
Study context
- Population
- Patients with clinically suspect arthralgia (CSA)
- Exposure
- CSA onset vs inflammatory arthritis (IA) development (progressors) or vs 24 months without IA (non-progressors); ACPA-positive vs ACPA-negative progressors
- Outcome
- Change in whole-blood RNA expression of 37 inflammatory cytokines, chemokines and related receptors
Methodological detailspaired samples, generalised estimating equations, false discovery rate approach
- Paired samples
- Generalised estimating equations
- False discovery rate approach
Main finding
As reported in the abstract
Cytokine/chemokine gene expression, CSA onset to IA development
- None of the cytokine/chemokine genes significantly changed in expression between CSA onset and IA development
Observational data: associations, not effects.
Further findings
Gene expression change in CSA without IA development · 2 years
- G-CSF expression decreased
- P = 0.001
- CCR6 expression increased
- P < 0.001
- TNIP1 expression increased
- P = 0.002
Expression in ACPA-positive vs ACPA-negative CSA patients developing IA
- Expression levels similar
Original publication
The course of cytokine and chemokine gene expression in clinically suspect arthralgia patients during progression to inflammatory arthritis. Rheumatology (Oxford). Published 6 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →