circ_0002970 promotes fibroblast-like synoviocytes invasion and the inflammatory response through Hippo/YAP signaling to induce CTGF/CCN1 expression in rheumatoid arthritis
Authors' conclusion
These findings highlight circ_0002970 as a novel regulator of RA-FLS migration, invasion, and inflammation via the Hippo-YAP signaling pathway.
Study context
- Population
- Synovial tissues from rheumatoid arthritis (RA) patients, osteoarthritis (OA) patients and healthy controls
- Comparison
- circ_0002970 knockdown or overexpression in RA-FLSs
Methodological detailsRNA sequencing, qRT-PCR, FISH and RNase R digestion assays, transfection, migration/invasion assays, ELISA and Western blotting
- RNA sequencing
- qRT-PCR, FISH and RNase R digestion assays
- Transfection, migration/invasion assays, ELISA and Western blotting
Main finding
As reported in the abstract
- Circ_0002970 significantly upregulated in RA-FLSs
- Knockdown of circ_0002970 suppressed RA-FLS migration, invasion and IL-6 secretion
- Knockdown downregulated Hippo-YAP pathway components (YAP, CTGF, CCN1) and decreased MMP-9 and MMP-13
- Verteporfin-mediated Hippo-YAP inhibition reversed the effects of circ_0002970 overexpression
Original publication
circ_0002970 promotes fibroblast-like synoviocytes invasion and the inflammatory response through Hippo/YAP signaling to induce CTGF/CCN1 expression in rheumatoid arthritis. Arthritis Res Ther. Published 25 April 2025. doi:10.
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