Regulation of fibroblast-like synoviocyte function by cadherin 6 in rheumatoid arthritis
Authors' conclusion
CDH6 expression is elevated in RA FLS due to epigenetic and local conditions of synovitis promoting migration, survival and cell growth, which are characteristic features of aggressive RA FLS.
Study context
- Population
- Rheumatoid arthritis (RA) or osteoarthritis (OA) patients undergoing joint replacement (synovial tissue and fibroblast-like synoviocytes (FLS))
- Comparison
- RA vs OA FLS; CDH6 siRNA knockdown
Methodological detailsin vitro, siRNA knockdown, public database analysis
- In vitro
- siRNA knockdown
- Public database analysis
Main finding
As reported in the abstract
- CDH6 expression higher in RA than OA FLS
- Associated with differential chromatin accessibility and histone marks in the CDH6 promoter of RA FLS; H3K27ac an important regulator of CDH6 expression (histone deacetylase inhibitor experiments)
- TGFß, but not IL-1β, TNF, IL-17A, IFNγ, IL-6 or PDGF, increased CDH6 expression of cultured RA FLS
- CDH6 knockdown significantly decreased RA FLS migration and cell growth, with increased apoptosis in CDH6-deficient FLS
- CDH6 protein in membrane, perinuclear and nuclear regions of cultured FLS
- In RA synovial tissue, CDH6 expressed in FLS and macrophages in lining and sublining
Original publication
Regulation of fibroblast-like synoviocyte function by cadherin 6 in rheumatoid arthritis. Arthritis Res Ther. Published 29 August 2025. doi:10.
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