RA and risk of colorectal cancer: a nationwide cohort study
Main finding · CRC incidenceResult — go to the resultHazard ratio 0.89 95% CI 0.79–0.99Authors' conclusion
Our analyses provide solid evidence of an inverse association between RA and CRC risk, particularly in patients with seronegative RA, rectal cancer cases and women.
Study context
- Population
- Korean National Health Insurance System database: patients with newly diagnosed RA 2010–2017 and matched non-RA participants2,174 incident colorectal cancer (CRC)
- Exposure
- RA vs matched non-RA participants
- RAn = 40,909
- Non-RAn = 204,545reference
- Outcome
- Incident CRC
Methodological detailsnationwide, matched by age and sex at a 1:5 ratio, multivariable Cox regression
- Nationwide
- Matched by age and sex at a 1:5 ratio
- Multivariable Cox regression
Main finding
CRC incidence · median follow-up 5.3 years
Hazard ratio
0.89
95% CI 0.79–0.99
Events by group
RA
319
events
Non-RA
1855
events
RAvs Non-RA
HR 0.89 (95% CI 0.79–0.99)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| CRC by RA serostatusSeronegative RAvs Non-RA | 0.79 (0.63–0.98) | ||
| CRC by RA serostatusSeropositive RAvs Non-RA | 0.93 (0.81–1.06) | ||
| CRC by subsiteRAvs Non-RARectal cancer | 0.63 (0.45–0.87) | ||
| CRC by subsiteRAvs Non-RAProximal colon cancer | 1.04 (0.79–1.39) | ||
| CRC by subsiteRAvs Non-RADistal colon cancer | 0.84 (0.64–1.11) | ||
| CRC in women (subgroup)RAvs Non-RA | 0.80 (0.69–0.94) | P for interaction = 0.043 | |
| 0.512Hazard ratio (log scale) |
Original publication
RA and risk of colorectal cancer: a nationwide cohort study. Rheumatology (Oxford). Published 26 August 2025. doi:10.
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