Risk of fracture among patients with rheumatoid arthritis according to serological status: a population-based retrospective cohort study
Main finding · Any fracturesResult — go to the resultAdjusted hazard ratio 1.68 95% CI 1.62–1.75Authors' conclusion
Patients with RA were at higher risk of fractures compared to those without RA, with even higher risk among those with SPRA. The risk of fractures remained elevated regardless of bDMARD or tsDMARD use
Study context
- Population
- Patients diagnosed with rheumatoid arthritis (RA) between 2010 and 2017 and age- and sex-matched controls, Korean National Health Insurance Service database
- Exposure
- RA vs matched controls; seropositive RA vs seronegative RA
- RAn = 43,677
- Matched controlsn = 131,031reference
- Outcome
- Any fractures
Methodological detailspopulation-based, matched on age and sex
- Population-based
- Matched on age and sex
Main finding
As reported in the abstract
Adjusted hazard ratio
1.68
95% CI 1.62–1.75
RAvs Matched controls
aHR 1.68 (95% CI 1.62–1.75)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Fractures by serological status (any, vertebral, hip)SPRAvs Seronegative RAAny fractures | 1.19 (1.11–1.28) | |
| Fractures by serological status (any, vertebral, hip)SPRAvs Seronegative RAVertebral fractures | 1.40 (1.26–1.55) | |
| Fractures by serological status (any, vertebral, hip)SPRAvs Seronegative RAHip fractures | 1.55 (1.19–2.02) | |
| 0.512Adjusted hazard ratio (log scale) |
Fracture risk in RA vs matched controls by bDMARD and tsDMARD exposure
- bDMARD exposed vs matched controls
- 2.28-fold
- bDMARD unexposed vs matched controls
- 1.64-fold
- tsDMARD exposed vs matched controls
- 1.91-fold
- tsDMARD unexposed vs matched controls
- 1.68-fold
Original publication
Risk of fracture among patients with rheumatoid arthritis according to serological status: a population-based retrospective cohort study. Osteoporos Int. Published 28 April 2026. doi:10.
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