Rheumatoid Arthritis and Risk of Depression in South Korea
Authors' conclusion
This nationwide cohort study found that both SPRA and SNRA were associated with a significantly higher risk of depression.
Study context
- Population
- Patients with rheumatoid arthritis (RA) and matched controls, Korean National Health Insurance Service database, enrolled 2010–2017, followed up until 2019; prior depression or depression within 1 year after index date excluded (mean age 54.6 years; 71.0% female)27,063 developed depression
- Exposure
- RA vs matched controls without RA
- RAn = 38,487
- Controlsn = 192,435reference
- Outcome
- Newly diagnosed depression (ICD-10 codes F32 or F33)
Methodological detailsmatched 1:5 for age, sex and index date, nationwide, Statistical analysis was performed in May 2023
- Matched 1:5 for age, sex and index date
- Nationwide
- Statistical analysis was performed in May 2023
Main finding
As reported in the abstract
Depression · median follow-up 4.1 (IQR 2.4-6.2) years
RA
6422
events
Controls
20 641
events
Each group vs controlsAdjusted hazard ratio (95% CI)
RA
1.66(1.61–1.71)
SPRA
1.64(1.58–1.69)
SNRA
1.73(1.65–1.81)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Depression by b/tsDMARD use in RA (subgroup)RA using b/tsDMARDsvs Controls | 1.33 (1.20–1.47) | |
| Depression by b/tsDMARD use in RA (subgroup)RA not using b/tsDMARDsvs Controls | 1.69 (1.64–1.74) | |
| 0.512Adjusted hazard ratio (log scale) |
Depression by b/tsDMARD use in RA (subgroup)
- Patients with RA who used b/tsDMARDs had a lower risk of depression than those who did not
Original publication
Rheumatoid Arthritis and Risk of Depression in South Korea. JAMA Netw Open. Published 4 March 2024. doi:10.
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