The role of ITIH4 in regulating the PI3K/Akt signalling in rheumatoid arthritis
Authors' conclusion
The study suggests that the ITIH4-CXCR4 interaction is linked to apoptosis and inflammation in RA through PI3K/Akt signalling.
Study context
- Population
- RA patients' plasma and PBMCs; RA fibroblast-like synoviocytes (RA-FLS); CIA rat model
- Comparison
- ITIH4 knockdown vs control in RA-FLS and CIA rats
Methodological detailsin vitro siRNA knockdown in RA-FLS, molecular dynamics simulation, CIA rat model
- In vitro siRNA knockdown in RA-FLS
- Molecular dynamics simulation
- CIA rat model
Main finding
As reported in the abstract
- Increased ITIH4 levels in RA patients' plasma and PBMCs
- ITIH4 positively interacted with CXCR4
- ITIH4 knockdown in RA-FLS: increased apoptosis and reduced pro-inflammatory cytokine production via PI3K/Akt signalling
- ITIH4 knockdown in CIA rats: significantly inhibited arthritis-like symptoms (decreased arthritis index, cellular infiltration, cytokines production and pannus formation)
Original publication
The role of ITIH4 in regulating the PI3K/Akt signalling in rheumatoid arthritis. Rheumatology (Oxford). Published 3 July 2025. doi:10.
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