Systemic sclerosis & Raynaud's
Risk of ischaemic and non-ischaemic heart failure in patients with systemic sclerosis: a population-based study
Authors' conclusion
SSc is associated with both ischaemic and non-ischaemic HF
Study context
- Population
- All patients with incident SSc in Sweden 2004–19 and general population comparatorsmatched cohort
- Participants
- 1,598 vs 16,616
- Exposure
- Incident SSc vs age- and sex-matched general population comparators
- SScn = 1,598
- Comparatorsn = 16,616reference
- Outcome
- Incident HF (ICD-10: I50) as main diagnosis, stratified into ischaemic and non-ischaemic HF
Methodological detailsnationwide Swedish registers, age- and sex-matched comparators (1:10), flexible parametric models
- Nationwide Swedish registers
- Age- and sex-matched comparators (1:10)
- Flexible parametric models
Main finding
As reported in the abstract
Incident HF overall
- HR for heart failure (HF) overall, SSc vs comparators, at end of first year of follow-up
- 5.7 (95% CI 4.2-7.9)
Observational data: associations, not effects.
Further findings
Ischaemic HF · end of first year of follow-up
- HR for ischaemic HF, SSc vs comparators
- 6.7 (95% CI 3.5-13.0)
- Ischaemic HF share of all HF cases in both groups
- 35%
Non-ischaemic HF · end of first year of follow-up
- HR for non-ischaemic HF, SSc vs comparators
- 5.8 (95% CI 4.0-8.3)
- Non-ischaemic HF share of all HF cases in both groups
- 65%
Original publication
Risk of ischaemic and non-ischaemic heart failure in patients with systemic sclerosis: a population-based study. Rheumatology (Oxford). Published 6 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →