Systemic sclerosis & Raynaud's
Association of Systemic Sclerosis With Incident Clinically Evident Heart Failure
Main finding · HF hospitalizationResult — go to the resultAdjusted hazard ratio 3.26 95% CI 2.49–4.28Authors' conclusion
SSc is associated with a markedly higher risk of clinically evident HF and not asymptomatic ventricular dysfunction alone.
Study context
- Population
- Incident systemic sclerosis (SSc) patients with no history of heart failure (HF) and matched non-SSc controls, nationwide insurance database, Taiwanmatched cohort
- Participants
- 1,830 vs 27,981
- Exposure
- SSc vs matched non-SSc individuals
- SScn = 1,830
- Non-SScn = 27,981reference
- Outcome
- HF hospitalization (clinically overt HF)
Methodological detailsmatched by age, sex and cohort entry time, nationwide insurance database, multivariable Cox proportional hazards regression
- Matched by age, sex and cohort entry time
- Nationwide insurance database
- Multivariable Cox proportional hazards regression
Main finding
HF hospitalization
Adjusted hazard ratio
3.26
95% CI 2.49–4.28
SScvs Non-SSc
aHR 3.26 (95% CI 2.49–4.28)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| HF, age <50 years (subgroup) | 7.8 (4.03–15.1) | |
| HF, age ≥50 years (subgroup) | 2.78 (2.06–3.76) | |
| 0.050.21520Hazard ratio (log scale) |
Cumulative incidence of hospitalized HF in SSc · 3, 5 and 10 years
- 3 years
- 3.5%
- 5 years
- 5.3%
- 10 years
- 9.7%
Original publication
Association of Systemic Sclerosis With Incident Clinically Evident Heart Failure. Arthritis Care Res (Hoboken). Published 12 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →