Systemic sclerosis & Raynaud's
Autologous fat or adipose-derived stem cells grafting in systemic sclerosis treatment: a systematic review and meta-analysis
Authors' conclusion
AF, SVF, and ADSC all displayed therapeutic effects of improving SSc, but differences existed in the effects on different symptoms.
Study context
- Population
- Patients with systemic sclerosis (SSc)
- Participants
- 15 studies
- Comparison
- Autologous fat (AF) vs stromal vascular fraction (SVF) vs adipose-derived stem cell (ADSC) grafting in SSc
Methodological detailsScreening, selection, data extraction and quality assessment performed independently by two authors
- Screening, selection, data extraction and quality assessment performed independently by two authors
Pooled result
As reported in the abstract
- Skin thickness reduced following SVF or AF therapy, but no significant difference
- All measures of fingertip symptoms revealed a significant improvement
- SVF and AF had the most impact on RP improvement
- ADSC improved the most in finger pain alleviation
Safety
- SVF reported the highest proportion of adverse events, approximately half of the cases
Original publication
Autologous fat or adipose-derived stem cells grafting in systemic sclerosis treatment: a systematic review and meta-analysis. Clin Exp Rheumatol. Published 10 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →