Systemic sclerosis & Raynaud's
Progression from suspected to definite systemic sclerosis and the role of anti-topoisomerase I antibodies
Authors' conclusion
Although a role of ATA in disease progression is suggested, more studies on the ATA response in suspected very early SSc are warranted.
Study context
- Population
- Patients with suspected very early systemic sclerosis (SSc) (literature) and patients with ATA-positive SSc from the Leiden Combined Care in Systemic Sclerosis (CCISS)-cohort
- Outcome
- Progression from suspected very early SSc to definite SSc (literature review)
- Follow-up
- 1-15 years
Methodological detailsLeiden CCISS-cohort
- Leiden CCISS-cohort
Main finding
As reported in the abstract
Proportion of patients with suspected very early SSc progressing to definite SSc
52%
Observational data: associations, not effects.
Original publication
Progression from suspected to definite systemic sclerosis and the role of anti-topoisomerase I antibodies. RMD Open. Published 6 February 2023. doi:10.
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