Systemic sclerosis & Raynaud's
Raynaud’s phenomenon is associated with an increased risk of cardiovascular disease and venous thromboembolism
Authors' conclusion
RP was associated with an increased risk of CVD and VTE, independent of age and traditional cardiovascular risk factors.
Study context
- Population
- Individuals with raynaud's phenomenon (RP) without underlying relevant systemic autoimmune rheumatic diseases (SARDs), North American electronic healthcare organization records30,088 matched pairs <45
- Exposure
- RP vs irritable bowel syndrome (IBS)
- Outcome
- Co-primary: Major adverse cardiovascular events (MACE) and venous thromboembolism (VTE)
Methodological details1:1 propensity score matched, Cox proportional hazard models, stratified by age (<45 and ≥45 years)
- 1:1 propensity score matched
- Cox proportional hazard models
- Stratified by age (<45 and ≥45 years)
Main finding
As reported in the abstract
RP vs IBSHazard ratio (95% CI)
MACE, age <45
1.23(1.07–1.42)
VTE, age <45
1.32(1.20–1.46)
MACE, age ≥45
1.17(1.13–1.22)
VTE, age ≥45
1.20(1.14–1.26)
Observational data: associations, not effects.
Secondary outcomes
Secondary outcomes (MI, stroke, any cardiovascular disease (CVD))
- Risk of secondary outcomes higher in RP; estimates for DVT in both analyses and MI in patients under 45 lacked precision
Original publication
Raynaud’s phenomenon is associated with an increased risk of cardiovascular disease and venous thromboembolism. Semin Arthritis Rheum. Published 5 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →