Systemic sclerosis & Raynaud's
Hopelessness is associated to severity of both digital vasculopathy and lung disease in systemic sclerosis patients: a prospective one-year study
Authors' conclusion
Hopelessness is common in SSc and linked to lung severity and digital vasculopathy
Study context
- Population
- Systemic sclerosis (SSc) patients followed prospectively over one year
- Participants
- 76 patients
- Exposure
- Moderate/severe hopelessness vs mild hopelessness
- Outcome
- Burden of hopelessness (Beck Hopelessness Scale) and its clinical and psychosocial correlates
Methodological detailsone-year follow-up, multivariate analysis
- One-year follow-up
- Multivariate analysis
Main finding
As reported in the abstract
Disease severity (MSS)
Beck Hopelessness Scale (BHS)>8
6
range or IQR 4–10
≤8
3
range or IQR 2–5
P = 0.008
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| MSS lung scores over timeWorse in moderate/severe hopelessness | P < 0.05 |
HAMIS, Raynaud's Condition Score (RCS) and ADL function
- BHS>8 associated with poorer HAMIS, RCS and ADL function
Multivariate association of hopelessness with Medsger Severity Score (MSS) lung, RCS and Body Image Scale (BIS)
- MSS lung scores: Coeff
- 0.490 (CI [0.030-0.957], p=0.037)
- RCS: Coeff
- 0.180 (CI [0.029-0.329], p=0.019)
- BIS: Coeff
- 0.229 (CI [0.165-0.292], p<0.001)
- Multivariate analysis
Hopelessness and DUCAS in patients with active digital ulcer (DU) (subgroup)
- DUCAS: Coeff
- 0.636 (CI [0.033-1.239], p=0.039)
Original publication
Hopelessness is associated to severity of both digital vasculopathy and lung disease in systemic sclerosis patients: a prospective one-year study. Clin Exp Rheumatol. Published 1 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →