Lupus & antiphospholipid syndrome
Risk factors for hospitalization in Mexican patients with systemic lupus erythematosus
Authors' conclusion
Disease activity was the most common reason for hospitalization; kidney, constitutional, and hematological factors were associated with hospitalization; and the use of antimalarial was a protective factor for hospitalization.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) in San Luis Potosí, Mexico, evaluated January 2019 to October 2020
- Participants
- 202 patients
- Comparison
- Hospitalized vs non-hospitalized SLE patients
- Hospitalizedn = 89
- Outcome
- Risk factors for hospitalization
Methodological detailsobservational
- Observational
Main finding
As reported in the abstract
Risk factors for hospitalization (multivariate analysis)
- Elevated creatinine, CRP, neutrophil levels and constitutional symptoms associated with hospitalization
- Antimalarial use a protective factor against hospitalization
Observational data: associations, not effects.
Further findings
- Hospitalization rate — Hospitalized
- 45.1%
Hospitalization rate
- Hospitalized patients were younger, had shorter disease duration, higher SLEDAI and more accumulated damage than non-hospitalized
Reasons for hospitalization
- Disease activity
- 60.7%
- Drug toxicity
- 5.6%
- Kidney disease and infection also reasons
Factors associated with mortality
- Prolonged international normalized ratio (INR), longer intensive care unit (ICU) stay and vasopressor use associated with mortality
- Hospital-acquired infections associated with lower probability of survival
Original publication
Risk factors for hospitalization in Mexican patients with systemic lupus erythematosus. Lupus. Published 26 April 2024. doi:10.
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