Lupus & antiphospholipid syndrome
Analysis of 5-year hospitalization data of patients with systemic lupus erythematosus: Damage is a risk factor for frequent and longer stays
Authors' conclusion
Disease activity, infections, and damage are the leading causes of hospitalization in SLE patients. Damage prolongs hospital stay and increases hospitalization rate and ICU need.
Study context
- Population
- Hospitalized systemic lupus erythematosus (SLE) patients admitted to a rheumatology clinic, 2015–2020
- Participants
- 161 patients298 hospitalizations
- Exposure
- Hospitalizations for active disease vs infection vs damage-related causes
- Outcome
- Factors leading to hospitalization
- Follow-up
- 5 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
SDI score by cause of hospitalization
| Outcome | Active disease | Infection |
|---|---|---|
| SDI score by cause of hospitalizationMean | 1.93 (SD 2.05) | 2.68 (SD 1.63) |
| Patients with damage | 68% | 90% |
- Active disease vs Infection / Damage-related: P < 0.05 — significantly lower in active disease
- Mean SLE damage index (SDI) correlated with hospitalization duration
- r = 0.551, p < .001
- Mean SDI correlated with number of hospitalizations
- r = 0.393, p < .001
Observational data: associations, not effects.
Further findings
Mean
| Outcome | Active disease | Infection | P value |
|---|---|---|---|
| SLEDAI-2K at admissionActive disease vs Infection / Damage-related | 11.03 (SD 6.08) | 3.21 (SD 2.80) | P < 0.001 |
- Readmissions and total hospital stay · Infection vs Active disease / Damage-related · significantly higher
- P < 0.05
- Readmissions and total hospital stay · Infection vs Active disease / Damage-related · longer
- P < 0.01
- SLEDAI-2K at admission: Damage-related mean 2.96 (SD 3.32)
Hospitalizations per patient and duration (all patients)
- Hospitalized more than once
- 38%
- Hospitalizations per patient, mean ± SD
- 1.85 ± 1.56
- Mean total hospitalization duration, days
- 25 ± 26.5
Organ involvement in active disease
- Renal
- 44%
- Hematological
- 34.8%
- Articular
- 21.7%
- Mucocutaneous
- 21%
Safety
- Patients admitted to intensive care unit (ICU), all with damage
- Ten percent
- Associated with ICU admission: total hospitalization duration, mean SDI, APS, LA, thrombocytopenia, serositis, pulmonary hypertension, history of alveolar hemorrhage, cardiac valve involvement
- P < 0.05 for all
Original publication
Analysis of 5-year hospitalization data of patients with systemic lupus erythematosus: Damage is a risk factor for frequent and longer stays. Lupus. Published 9 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →